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Bioprinting and Differentiation of Adipose-Derived Stromal ...- adipose tissue cells stromal tumor ,In breast cancer, adipose tissue has been acknowledged as an important part of the tumor microenvironment favoring tumor progression. Therefore, in this study, a 3D-printed breast cancer model for facilitating investigations into cancer cell-adipocyte interaction was developed.Bioprinting and Differentiation of Adipose-Derived Stromal ...Apr 03, 2021·Together, our data demonstrate that 3D-printed breast cancer-adipose tissue models can recapitulate important aspects of the complex cell–cell and cell–matrix interplay within the tumor …



Cells | Free Full-Text | Adipose Stromal Cell Expansion ...

Adipose tissue (AT) is comprised of a diverse number of cell types, including adipocytes, stromal cells, endothelial cells, and infiltrating leukocytes. Adipose stromal cells (ASCs) are a mixed population containing adipose progenitor cells (APCs) as well as fibro-inflammatory precursors and cells supporting the vasculature. There is growing evidence that the ability of ASCs to renew and ...

Adipose tissue-derived stromal cells are sources of cancer ...

/ Adipose tissue-derived stromal cells are sources of cancer-associated fibroblasts and enhance tumor progression by dense collagen matrix. In: International Journal of Cancer. 2019 ; …

Adipose Stem Cells and Cancer: Concise Review - Sabol ...

Jul 04, 2019·It is well established that the tumor microenvironment plays an important role in cancer development and progression. The tumor microenvironment is composed of neoplastic cells, endothelial cells, pericytes, adipocytes, fibroblasts and other connective tissue cells, extracellular matrix components, multiple stem and progenitor cells, and a diverse array of innate and adaptive immune cells …

White Adipose Tissue Cells Are Recruited by Experimental ...

Jun 15, 2009·The connection between obesity and accelerated cancer progression has been established, but the mediating mechanisms are not well understood. We have shown that …

Ex vivo‐expanded autologous adipose tissue‐derived stromal ...

Jul 08, 2020·a Drop out 1: Due to overconfluency of the adipose-derived stromal cells, resulting in loss of cells during the harvesting procedure, leaving too few cells to reach the desired concentration. Drop out 2: A malignant melanoma was diagnosed prior to the breast augmentation procedure.

Cells | Special Issue : Adipose-Derived Stromal/Stem Cells

Jan 31, 2020·During cancer progression, breast tumor cells interact with adjacent adipose tissue, which has been shown to be engaged in cancer aggressiveness. However, the tumor-directed changes in adipose tissue-resident stromal cells affected by the tumor…

Bioprinting and Differentiation of Adipose-Derived Stromal ...

Biofabrication, including printing technologies, has emerged as a powerful approach to the design of disease models, such as in cancer research. In breast cancer, adipose tissue has been acknowledged as an important part of the tumor microenvironment favoring tumor progression. Therefore, in this study, a 3D-printed breast cancer model for facilitating investigations into cancer cell-adipocyte ...

Adipocyte heterogeneity revealed by spatial ... - cell

Sep 07, 2021·Adipose tissue is composed of adipocytes and cells from the stromal vascular fraction. In this issue of Cell Metabolism, Bäckdahl et al. use spatial transcriptomics to provide a first glimpse at the architecture of human adipose tissue. The authors identify distinct adipocyte subpopulations with specific metabolic features.

Differential effects of adipose tissue stromal cells on ...

Adipose tissue stromal cells promoted display of the molecular-targeted agent human epidermal growth factor receptor-2 in only RT4. In turn, RT4 and EJ enhanced …

Bioprinting and Differentiation of Adipose-Derived Stromal ...

Biofabrication, including printing technologies, has emerged as a powerful approach to the design of disease models, such as in cancer research. In breast cancer, adipose tissue has been acknowledged as an important part of the tumor microenvironment favoring tumor progression. Therefore, in this study, a 3D-printed breast cancer model for facilitating investigations into cancer cell-adipocyte ...

Tumor Necrosis Factor‐α Stimulates Cell Proliferation in ...

Sep 06, 2012·Discussion: These data suggest that paracrine levels (0.2 nM) of TNF-α alone or in combination with IGF-I may support adipose tissue development by increasing the total number of stromal-vascular and/or uncommitted cells within the tissue. These cells may then be recruited to become preadipocytes or may alternatively serve as infrastructure to ...

Progression of prostate carcinoma is promoted by adipose ...

Mar 22, 2021·Zhang, Y. et al. Stromal progenitor cells from endogenous adipose tissue contribute to pericytes and adipocytes that populate the tumor microenvironment. Cancer …

1. Mesenchymal Stem/Stromal Cells (MSCs)

1. Mesenchymal Stem/Stromal Cells (MSCs) MSCs are multipotent stromal cells with the capacity for self-renewal and differentiation. They were originally identified in bone marrow (BM) [1,2] and, currently, cells with similar characteristics can be obtained from different tissues [3,4,5].Three biological properties have been identified in BM-MSCs: (a) differentiation potential, (b) secretion of ...

Adipose-derived mesenchymal stem cells and extracellular ...

Jul 01, 2020·Adipocytes are the most abundant stromal cells and a critically important in breast tissue but often overlooked component in the tumor microenvironment. Adipose tissue has been one of the most studied tissues in recent ten years due to its endocrine activity which is conferred by secretion of adipocytokines, transcriptional, hormones, cytokines ...

Cancer as a Matter of Fat: The Crosstalk between Adipose ...

May 01, 2018·Adipose Tissue Inflammation and Cancer Initiation. Inflammation is a hallmark of cancer that underlies obesity-linked carcinogenesis. Tumors can be considered as wounds that ‘do not heal’ due to chronic inflammation induced by immune cells .In WAT, innate and adaptive immune cells constitute almost half of the population of lipid-free cells in the stromal–vascular fraction.

Interactions of BRCA1-mutated Breast Cancer Cell Lines ...

Jul 06, 2021·Lipofilling may constitute a technique to assist reconstruction of breasts following prophylactic mastectomy for patients with mutated BRCA1 or BRCA2 genes. However, to date it is not clear whether adipose-derived stromal cells (ADSCs) increase the risk of tumor initiation and progression in this situation. Therefore, the interactions of BRCA1 mutated breast cancer cell lines …

(PDF) Isolation and characterization of canine ...

Of particular interest to the field of bone tissue engineering, models have been well-described in canine using adipose derived stem/ stromal cells (ASC) for the treatment of cranial defects[38], segmental bone defects[39], radial and ulnar nonunion fractures[40], and osteoarthritis[41, 42].

Adipose-derived mesenchymal stem cells and extracellular ...

Jul 01, 2020·Adipocytes are the most abundant stromal cells and a critically important in breast tissue but often overlooked component in the tumor microenvironment. Adipose tissue has been one of the most studied tissues in recent ten years due to its endocrine activity which is conferred by secretion of adipocytokines, transcriptional, hormones, cytokines ...

Studying Adipose Tissue in the Breast Tumor ...

Sep 16, 2020·The breast cancer microenvironment contains a variety of stromal cells that are widely implicated in worse patient outcomes. While many in vitro models of the breast tumor microenvironment have been published, only a small fraction of these feature adipocytes. Adipocytes are a cell type increasingly recognized to have complex functions in breast cancer.

Effect of MicroRNA-146a Modified Adipose-Derived Stem Cell ...

Adipose tissue-derived stromal cells (ATSCs) have recently gained widespread attention as a potential alternate source to bone marrow-derived mesenchymal stem cells with a proliferative capacity ...

Adipose Tissue‐Derived Multipotent Stromal Cells Have a ...

May 21, 2013·Adipose tissue-derived multipotent stromal cells (AT-MSCs) are studied as an alternative to bone marrow-derived multipotent stromal cells (BM-MSCs) for immunomodulatory treatment. In this study, we systematically compared the immunomodulatory capacities of BM-MSCs and AT-MSCs derived from age-matched donors.

Targeted Proapoptotic Peptides Depleting Adipose Stromal ...

Jan 01, 2016·While the mechanisms linking obesity and cancer are complex, 7 our studies in mouse models have shown that recruitment of WAT-derived MSC, termed adipose stromal cells (ASC), is associated with accelerated tumor growth. 8 ASC, as well as adipocytes differentiating from them and WAT-infiltrating leukocytes, contribute to the production of ...

Adipose tissue-derived stromal cells are sources of cancer ...

Here, we investigated the roles of adipose tissue-derived stromal cells (ASCs) in desmoplastic lesions and tumor progression by in vitro and in vivo …

Stromal cell - Wikipedia

Stromal cells, or mesenchymal stromal cells, are differentiating cells found in abundance within bone marrow but can also be seen all around the body.Stromal cells can become connective tissue cells of any organ, for example in the uterine mucosa (endometrium), prostate, bone marrow, lymph node and the ovary.They are cells that support the function of the parenchymal cells of that organ.

The utility of adipose-derived stem cells and stromal ...

Aug 01, 2017·Stromal cells are connective tissue cells of any organ. Although often used interchangeably, adipose-derived stem cells (ASCs) and stromal vascular fraction (SVF) are distinct but associated entities within the field of regenerative medicine, each having different inherent attributes.

Endothelial Differentiation of Adipose Tissue ... - Cell

Sep 01, 2013·Multipotent human adipose tissue mesenchymal stromal cells (hAMSCs) are promising therapy vehicles with tumor-homing capacity that can be easily modified to deliver cytotoxicity activating systems in the proximity of tumors. In a previous work, we observed that hAMSCs are very effective delivering cytotoxicity to glioma tumors. However, these results were difficult to reconcile with the ...

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