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Connective Tissue Growth Factor Is a Mediator of ...- connective tissue growth factor fibrosis blood test ,Sep 02, 2003·Connective tissue growth factor (CTGF) is a novel and potent profibrotic factor, a member of the CCN family (cysteine-rich61, CTGF, and nephroblastoma overexpressed) of early immediate genes. CTGF is implicated in fibroblast proliferation, cellular adhesion, angiogenesis, and …Interleukin-15 attenuates transforming growth factor-β1 ...We have previously described an association between serum IL-15 levels and the extent of pulmonary fibrosis in the connective tissue disease systemic sclerosis, suggesting that IL-15 may have profibrotic effects. To test this hypothesis, we studied the effects of IL-15 on myofibroblast differentiation, an in vitro model of fibrosis development.



Connective tissue growth factor promoter activity in ...

Oct 13, 2008·In skin, connective tissue growth factor (CTGF/CCN2) is induced during tissue repair. However, what the exact cell types are that express CTGF in normal and wounded skin remain controversial. In this report, we use transgenic knock-in mice in which the Pacific jellyfish Aequorea victoria enhanced green fluorescent protein (E-GFP) gene has been inserted between the …

Connective tissue growth factor mRNA expression is ...

Aug 01, 1998·connective tissue growth factor (CTGF) is a newly described fibroblast mitogen and promoter of collagen deposition. CTGF was first isolated from human umbilical artery endothelial cells and subsequently was found to be expressed by human foreskin and dermal fibroblasts but not by other cell types such as epithelial cells or leukocytes ().It is a 38-kDa, cysteine-rich peptide and shares ...

Monitoring of Liver Fibrogenesis and Biochemical Diagnosis ...

Jan 01, 2017·Connective tissue growth factor in serum as a new candidate test for assessment of hepatic fibrosis Clin. Chem. , 52 ( 2006 ) , pp. 1815 - 1817 …

Connective Tissue Growth Factor Biomarker Detail

Connective Tissue Growth Factor (CTGF) CTGF (connective tissue growth factor) is a 349-amino acid cysteine-rich polypeptide belonging to the CCN family. In vitro studies have shown that CTGF is mainly involved in extracellular matrix synthesis and fibrosis. Upregulation of CTGF mRNA and an increase of CTGF protein levels has been observed in ...

Selective deletion of connective tissue growth factor ...

May 01, 2021·Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis Jan J. Rheumatol. , 27 ( 1 ) ( 2000 ) , pp. 149 - 154

(PDF) Connective Tissue Growth Factor in Serum as a New ...

CCN-2 (connective tissue growth factor; CTGF) is a key factor in fibrosis. Plasma CCN-2 has biomarker potential in numerous fibrotic disorders, but it is unknown which pathophysiological factors ...

(PDF) Connective tissue growth factor: Just another factor ...

Connective tissue growth factor (CTGF) is a profibrotic growth factor, which is upregulated in wound healing and renal fibrosis, including anti-Thy-1.1 nephritis.

Selective Expression of Connective Tissue Growth Factor in ...

Objective: Connective tissue growth factor (CTGF) is a cysteine-rich secreted matricellular protein involved in wound healing and tissue repair. Enhanced and …

Connective Tissue Growth Factor Biomarker Detail

Connective Tissue Growth Factor (CTGF) CTGF (connective tissue growth factor) is a 349-amino acid cysteine-rich polypeptide belonging to the CCN family. In vitro studies have shown that CTGF is mainly involved in extracellular matrix synthesis and fibrosis. Upregulation of CTGF mRNA and an increase of CTGF protein levels has been observed in ...

Frontiers | Connective Tissue Growth Factor: From ...

Oct 29, 2020·Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such as cell proliferation, angiogenesis, and wound healing, as well as multiple pathologies, such as tumor development and tissue fibrosis. Although the underlying mechanisms of CTGF remain incompletely understood, a commonly accepted theory is that the …

Connective Tissue Growth Factor Is Crucial to Inducing a ...

Fibrosis-prone mice have higher levels of chemokines (regulated upon activation, normal T cell expressed and secreted, interferon-inducible protein 10, macrophage inhibitory protein–1γ) , or growth factors, such as transforming growth factor (TGF)–β (9, 10), in lung tissues after irradiation or bleomycin exposure compared with fibrosis ...

Connective Tissue Growth Factor and Cardiac Fibrosis after ...

Oct 01, 2005·The temporal and spatial expression of transforming growth factor (TGF)-β 1 and connective tissue growth factor (CTGF) was assessed in the left ventricle of a myocardial infarction (MI) model of injury with and without angiotensin-converting enzyme (ACE) inhibition. Coronary artery ligated rats were killed 1, 3, 7, 28, and 180 days after MI.

The Clinical Value of Serum Connective Tissue Growth ...

Mar 18, 2009·高达10%返现·To explore the relation between connective tissue growth factor (CTGF) in serum and the severity of liver fibrosis, and to determine the clinical value of CTGF …

Susceptibility to liver fibrosis in mice expressing a ...

Aug 27, 2009·Connective tissue growth factor (CCN2) is a matricellular protein that is up-regulated in many fibrotic disorders and coexpressed with transforming growth factor β. CCN2 promotes fibrogenesis and survival in activated hepatic stellate cells, and injured or fibrotic liver contains up-regulated levels of CCN2 that are produced by a variety of ...

Increased expression of hypoxia-inducible factor-1α and ...

May 01, 2012·Increased expression of hypoxia-inducible factor-1α and connective tissue growth factor accompanied by fibrosis in the rat testis of varicocele Expresión aumentada del factor inducible por hipoxia 1α y del factor de crecimiento del tejido conectivo acompañando a fibrosis en testículos de ratas con varicocele ☆

Frontiers | Connective Tissue Growth Factor Is ...

May 25, 2021·Introduction. Connective tissue growth factor (CTGF, CCN2), a cysteine-rich matricellular protein, is an important profibrotic mediator in several fibrotic disorders, including idiopathic pulmonary fibrosis (IPF) (1, 2).In IPF, promising results of the PRAISE trial were recently published, which was a phase II randomized trial of Pamrevlumab (FG-3019), a fully recombinant human …

Selective expression of connective tissue growth factor in ...

Apr 29, 2010·Connective tissue growth factor (CTGF) is a cysteine‐rich secreted matricellular protein involved in wound healing and tissue repair. Enhanced and prolonged expression of CTGF has been associated with tissue fibrosis in humans. However, questions remain as to whether CTGF expression alone is sufficient to drive fibrosis.

Connective tissue growth factor is correlated with ...

Aug 21, 2019·Connective tissue growth factor (CTGF) is a member of the CCN (CTGF/Cyr61/Nov) family and is an important player in the pathogenesis of fibrotic disorders. CTGF is …

Tamoxifen downregulates connective tissue growth factor to ...

Human peritoneal mesothelial cells (HPMC) were used as an in vitro model to test the antifibrotic effect of tamoxifen. Gene expressions of transforming growth …

Deletion of connective tissue growth factor ameliorates ...

Nov 17, 2017·Connective tissue growth factor (CTGF/CCN2) regulates the signalling of other growth factors and promotes fibrosis. CTGF is increased in mice and humans with peritoneal fibrosis. Inhibition of CTGF has not been examined as a potential therapeutic target for peritoneal fibrosis because systemic CTGF knockout mice die at the perinatal stage.

Connective tissue growth factor (CTGF/CCN2) is increased ...

Mar 01, 2010·Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. FASEB J 16: 219–221, 2002. Crossref | PubMed | ISI | Google Scholar; 19. Ito Y , Aten J , Bende RJ , Oemar BS , Rabelink TJ , Weening JJ , Goldschmeding R. Expression of connective tissue growth factor in human renal fibrosis.

Selective deletion of connective tissue growth factor ...

Connective tissue growth factor (CTGF, CCN2) is a matricellular protein which plays key roles in normal mammalian development and in tissue homeostasis and …

Evaluation of serum connective tissue growth factor [CTGF ...

Clinical and experimental studies have demonstrated that connective-tissue growth factor [CTGF] expression is increased in fibrotic human liver and experimental animal models of liver fibrogenesis. CTGF has been linked to transforming growth factor-beta …

(PDF) Autologous bone marrow-derived mesenchymal stem ...

Sep 07, 2021·TGF-b1: transforming growth factor b1; CTGF: connective tissue growth factor; BM-MSCs: bone marrow-derived mesenchymal stem cells. Figures - …

Connective tissue growth factor production by activated ...

Apr 05, 2010·Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals. J Cell Comm Signaling 2009; doi10.1007/s12079–009–0071–5. Download references

Plasma CCN2/connective tissue growth factor is associated ...

Jan 06, 2010·Carcinoid heart disease, a known complication of neuroendocrine tumors, is characterized by right heart fibrotic lesions. Carcinoid heart disease has traditionally been defined by the degree of valvular involvement. Right ventricular (RV) dysfunction due to mural involvement may also be a manifestation. Connective tissue growth factor (CCN2) is elevated in many fibrotic disorders.

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