tissue-resident memory t cells orchestrate tumour-immune equilibrium

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Tissue-resident memory T cells orchestrate tumour-immune ...- tissue-resident memory t cells orchestrate tumour-immune equilibrium ,Abstract. The immune system can prevent tumour development by engaging in a process termed cancer immunosurveillance, during which immune cells such as T cells restrict tumour growth either by completely eradicating cancer cells in a process of ‘elimination’ or by suppressing cancer cell outgrowth by establishing a state of tumour-immune ‘equilibrium’.Dr Jason Waithman - Telethon Kids InstituteTissue-resident memory T cells orchestrate tumour-immune equilibrium Our findings provide insight into the immune cell populations important for maintaining long-term tumour dormancy in peripheral tissues. Published research Cancer Immunotherapy



Thomas Gebhardt's research works | University of Melbourne ...

Thomas Gebhardt's 88 research works with 5,950 citations and 12,966 reads, including: Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8+ T cells in skin

Author Correction: Tissue-resident memory CD8 + T cells ...

Feb 01, 2019·Author Correction: Tissue-resident memory CD8 + T cells promote melanoma-immune equilibrium in skin. Simone L Park Department of Microbiology and Immunology, , The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.

Tissue-resident memory T cells at the center of immunity ...

Immune responses in tissues are constrained by the physiological properties of the tissue involved. Tissue-resident memory T cells (T RM cells) are a …

Tissue-resident memory T cells at the center of immunity ...

May 18, 2018·Immune responses in tissues are constrained by the physiological properties of the tissue involved. Tissue-resident memory T cells (TRM cells) are a recently discovered lineage of T cells ...

Tissue-Resident Memory T Cells - Immunity

Tissue-resident memory T (Trm) cells are a recently defined T cell subset that does not recirculate and accelerates local pathogen clearance. Schenkel and Masopust summarize current knowledge of Trm cell ontogeny, regulation, maintenance, and function and highlight technical considerations for studying this cell …

Tissue-resident memory T cells orchestrate tumour-immune ...

Tissue-resident memory T cells orchestrate tumour-immune equilibrium. Download. published version (439.3Kb) Citations. Scopus. Altmetric. 1. Author Park, SL; Mackay, LK; Waithman, J; Gebhardt, T. Date 2019-05-01. Source Title Cell Stress. Publisher SHARED SCIENCE PUBLISHERS OG. University of Melbourne Author/s

Tissue-Resident Memory T Cells in Cancer ...

Following their activation and expansion in response to foreign threats, many T cells are retained in peripheral tissues without recirculating in the blood. These tissue-resident CD8+ memory T (TRM) cells patrol barrier surfaces and nonlymphoid organs, where their critical role in …

A/Prof Thomas Gebhardt and PhD Simone Park's study on ...

Jan 23, 2019·Associate Professor Thomas Gebhardt and PhD Simone Park (Dept. Microbiology & Immunology, Doherty Institute)'s study on tissue resident memory T (TRM) cells' role in controlling melanoma, 'Tissue-resident memory CD8+ T cells promote melanoma-immune equilibrium in skin', was recently published in Nature and received Australian and international coverage.

Tissue-resident memory T cells orchestrate tumour-immune ...

Abstract. The immune system can prevent tumour development by engaging in a process termed cancer immunosurveillance, during which immune cells such as T cells restrict tumour growth either by completely eradicating cancer cells in a process of ‘elimination’ or by suppressing cancer cell outgrowth by establishing a state of tumour-immune ‘equilibrium’.

Tissue-resident memory CD8( ) T cells promote melanoma ...

Although cancers most frequently originate in epithelial layers, the nature and spatiotemporal dynamics of immune responses that maintain cancer-immune equilibrium in these tissue compartments remain unclear. Here, using a mouse model of transplantable cutaneous melanoma5, we show that tissue-resident memory CD8+ T cells (TRM cells) promo..

Ms Simone Park - Find an Expert

Simone is an NHMRC Emerging Leadership Postdoctoral Fellow in the L. Mackay Laboratory at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne. She completed her PhD in 2019, during which she uncovered important roles for immune cells known as tissue-resident memory T cells in protection against cancer and viral infections.

Holding our breath: the promise of tissue-resident memory ...

Jul 07, 2020·T cell memory is critical in controlling infection and plays an important role in anti-tumor responses in solid cancers. While effector memory and central memory T cells circulate and patrol non-lymphoid and lymphoid organs respectively, tissue resident memory T cells (T RM) permanently reside in tissues and provide local protective immune responses.

Tissue-resident memory T cells at the center of immunity ...

May 18, 2018·Immune responses in tissues are constrained by the physiological properties of the tissue involved. Tissue-resident memory T cells (TRM cells) are a recently discovered lineage of T cells ...

Tissue-resident memory-like T cells in tumor immunity ...

Jun 01, 2020·Tissue-resident memory (T RM) T cells are distinct population of non-circulating lymphocytes that play an important role in mediating regional immunity.T RM - like cells have now been identified as a component of tumor-infiltrating lymphocytes in several human tumors and correlate with outcome and response to immunotherapy. T RM cells have also been shown to mediate anti-tumor immunity in ...

Regulatory T cells in tumor ... - Molecular Cancer

Jul 17, 2020·Regulatory T cells (Tregs), as an important mechanism for regulating homeostasis of the immune system and the immune tolerance of the body, play crucial roles in the regulation of tumour immunity and constitute a current research hotspot in the field, primarily as potential targets (Supplementary Table 1) that can inhibit the activation and differentiation of CD4 + helper T cells and CD8 ...

Pathogen-Boosted Adoptive Cell Transfer Therapy Induces ...

To avoid tumor growth at the site of the primary tumor, induction of a newly discovered subset of memory cells, known as tissue-resident memory (T RM) cells, is essential . T RM cells were first discovered in an infection model ( 12 ), where they provide first-line protection at the portal of pathogen entry during a …

Tissue-Resident Memory T Cells in Cancer ...

Aug 01, 2019·The hallmark feature of T RM cells is a lack of equilibration with the circulating memory T (T CIRC) cell pool . Parabiosis, organ transplantation, and targeted antibody-mediated T cell depletion experiments in mice have proven the existence of non-recirculating CD8 + T RM cells in diverse tissues, including the skin, lung, gut, liver, and reproductive tract, as well as in lymphoid organs .

Tissue-resident memory T cells: local specialists in ...

T cells have crucial roles in protection against infection and cancer. Although the trafficking of memory T cells around the body is integral to their …

Frontiers | Expanding Roles for CD4 T Cells and Their ...

The importance of CD4 T cells in orchestrating the immune system and their role in inducing effective T cell-mediated therapies for the treatment of patients with select established malignancies are undisputable. Through a complex and balanced array of direct and indirect mechanisms of cellular activation and regulation, this functionally diverse family of lymphocytes can potentially promote ...

Accumulation of CD103 + CD8 + T cells in a cutaneous ...

Notably, almost every single melanoma cell in the micrometastasis was in close proximity to these T RM-like cells. Conclusion: Such results support the emerging concept that CD103 + CD8 + T RM cells are key mediators of cancer surveillance and imply an important function of these cells in controlling clinically occult micrometastases in humans.

T‐cell memory in tissues - Gisbergen - 2021 - European ...

Apr 10, 2021·Adaptive tissue-resident memory can be maintained for years and results from tissue infiltrating T (including CD4 +, CD8 +, NKT, and γδ T cells) and B cells, the latter differentiating into memory B and plasma cells. Orange indicates reprogramming for more rapid effector functions upon secondary stimulation.

Fatty Acid Oxidation Controls CD8+ Tissue-Resident Memory ...

The success of checkpoint inhibitors in cancer treatment is associated with the infiltration of tissue-resident memory T (Trm) cells. In this study, we found that about 30% of tumor-infiltrating lymphocytes (TIL) in the tumor microenvironment of gastric adenocarcinoma were CD69+CD103+ Trm cells. Trm cells were low in patients with metastasis, and the presence of Trm cells was associated with ...

Tissue-resident memory T cells orchestrate tumour-immune ...

The immune system can prevent tumour development by engaging in a process termed cancer immunosurveillance, during which immune cells such as T cells...

Tissue-Resident Memory T Cells - Immunity

Tissue-resident memory T (Trm) cells are a recently defined T cell subset that does not recirculate and accelerates local pathogen clearance. Schenkel and Masopust summarize current knowledge of Trm cell ontogeny, regulation, maintenance, and function and highlight technical considerations for studying this cell …

Laura MACKAY | NHMRC Career Development Fellow | PhD ...

Tissue-resident memory T (Trm) cells contribute to local immune protection in non-lymphoid tissues such as skin and mucosa, but little is known about their transcriptional regulation.

Tissue-resident memory T cells orchestrate tumour-immune ...

Apr 26, 2019·Search worldwide, life-sciences literature Search. Advanced Search Coronavirus articles and preprints Search examples: "breast cancer" Smith J

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